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2 edition of Diethylnitrosamine, ethylnitrosourea, and dimethylbenz(a)anthracene DNA binding studies in the rainbow trout found in the catalog.

Diethylnitrosamine, ethylnitrosourea, and dimethylbenz(a)anthracene DNA binding studies in the rainbow trout

Samina Van Winkle

Diethylnitrosamine, ethylnitrosourea, and dimethylbenz(a)anthracene DNA binding studies in the rainbow trout

by Samina Van Winkle

  • 175 Want to read
  • 14 Currently reading

Published .
Written in English

    Subjects:
  • Polycyclic aromatic hydrocarbons -- Physiological effect.,
  • Carcinogens.,
  • Rainbow trout -- Metabolism.

  • Edition Notes

    Statementby Samina Van Winkle.
    The Physical Object
    Pagination153 leaves, bound :
    Number of Pages153
    ID Numbers
    Open LibraryOL15528944M

      1. Cancer Lett. Jan 18;(2) Nine-week detection of six genotoxic lung carcinogens using the rasH2/BHT mouse model. Umemura T(1), Kodama Y, Nishikawa A, Hioki K, Nomura T, Kanki K, Kuroiwa Y, Ishii Y, Kurokawa Y, Hirose M. Diethylnitrosamine (DEN)-induced carcinogenic liver injury in mice R Tolba1, T Kraus2, C Liedtke3, M Schwarz4 and R Weiskirchen5 Abstract The toxic properties of various nitrosamines in animals and humans are well established. The parenteral or oral administration of the smallest quantities of diethylnitrosamine (DEN) or dimethylnitrosamine (DMN).

    Dimethylnitrosamine definition, a yellow, water-soluble carcinogenic liquid, C2H6N2O, found in tobacco smoke and certain foods: known to be a potent carcinogen. Abbreviation: DMN, DMNA See more. Persistence of preclastogenic damage in hepatocytes of rats exposed to ethylnitrosourea, diethylnitrosamine, dimethylnitrosamine and methyl methanesulphonate. p'-diaminodiphenylmethane of 7, dimethylbenz[a]anthracene-induced carcinogenesis of the mammary gland and ear Book Review. Book review. J. Weber. Carcinogenesis, Volume 7.

    Title: Implementation ofthe Cancer Guidelines and Accompanying Supplemental Guidance -Science Policy Council Cancer Guidelines Implementation Workgroup Communication II: Performing Risk Assessments that include Carcinogens Described in the Supplemental Guidance as having a . dimethylbenz[a]anthracene, dimethylnitrosamine, dipropylnitrosamine and ethylnitrosourea (ENU)], four non- genotoxic hepatocarcinogens [carbon tetrachloride, di(2-ethylhexyl)phthalate (DEHP), phenobarbital and.


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Diethylnitrosamine, ethylnitrosourea, and dimethylbenz(a)anthracene DNA binding studies in the rainbow trout by Samina Van Winkle Download PDF EPUB FB2

Diethylnitrosamine, ethylnitrosourea, and dimethylbenz(a)anthracene DNA and dimethylbenz book studies in the rainbow trout Public Deposited.

Dimethylbenz (a) anthracene (EMBA), a carcinogen that requires metabolic activation to produce active metabolites capable of binding to DNA, has been studied in the trout and other fish.

Author: Samina Van Winkle. Diethylnitrosamine, ethylnitrosourea, and dimethylbenz(a)anthracene DNA binding studies in the rainbow trout. Title; And dimethylbenz book. Ethylnitrosourea. And nimprhhylbenz (a) anthracene CMA Binding Studies In The Rainbow Trout.

Abstract approved: - f George S. Bailey Dimethylbenz (a) anthracene (EMBA), a carcinogen that requires metabolic activation to produce active and dimethylbenz book capable of binding to ENA, has been studied in the trout and other fish. 1. Introduction.

Diethylnitrosamine (DEN) and ethylnitrosourea (ENU) are potent genotoxic N-nitroso carcinogens that induce hepatocellular carcinomas in mouse liver.It has been reported that after its metabolic biotransformation, DEN produces the promutagenic adducts O 6-ethylguanine (O 6-EtG) and O 4 - and O 2-ethylthymine and that O 4-ethylthymine may be responsible Cited by: nitrosamine, ENU, o-aminoazotoluene, 7,1 2-dimethylbenz[a] anthracene, dibenzo[ a, l ]pyrene, phenobarbital and ethanol expo- sure in mouse liver for 4 and 20 h and 14 and 28 days in our.

A Diethylnitrosamine study with four successive generations of Syrian hamsters was conducted to determine whether a single s.c. injection of different doses of diethylnitrosamine (DEN) (,5, 10, and 20 mg/kg body weight) on day 15 of pregnancy induces respiratory tract tumors not only in the treated P generation mothers and their F1 progeny but also in F2 and F3 generations.

In this. A multigeneration study with four successive generations of Syrian hamsters was conducted to determine whether a single s.c. injection of different doses of diethylnitrosamine (DEN) (,5. Treatment with carcinogens was long ago observed to produce tumors in these animals (Pliss et al., ), and treatment with mutagens such as ethylnitrosourea (ENU), dimethylbenz(a)anthracene.

A 9-week in vivo rasH2/butylhydroxytoluene (BHT) model for the detection of genotoxic lung carcinogens was validated, using six potent positive test compounds, dimethylnitrosamine (DMN; 15 mg/kg, i.p.), diethylnitrosamine (DEN; mg/kg, i.p.), ethylnitrosourea (ENU; mg/kg, i.p.), 3-methylcholanthrene (MC; mg/kg, i.p.), 7,dimethylbenz(a)anthracene (DMBA; 5 mg/kg, i.g.).

N-Nitrosodiethylamine (NDEA) is an organic compound with the formula Et2NNO (Et = C2H5). A member of the nitrosamines, it is carcinogenic and mutagenic. It is a pale yellow liquid with an amine or aromatic odor.

It is found in tobacco smoke. It is classified as a Group 2A carcinogen (probable human carcinogen) by the World Health Organization. References. Nb rats were either exposed in utero to various dose levels of N-ethylnitrosourea (ENU) on day 18 ± 1 of gestation, injected s.c.

with one 25 mg/kg dose of dimethylnitrosamine (DMN) as neonates or dosed twice orally with 7,dimethylbenz[a]anthracene (DMBA) shortly after ovariectomy.

Transplancental ENU at a dose of 60 mg/kg resulted in an. ethylnitrosourea (ENU) (3), convincingly demon- Diethylnitrosamine Rat I Diethylnitrosamine Mouse I Diethylnitrosamine Hamster ' Benzo[a]pyrene Mouse I 7,Dimethylbenz[a]-Mouse I anthracene 7,Dimethylbenz[a]-Rat I anthracene Estrogens Diethylstilbestrol Diethylstibestrol Diethylstilbestrol Miscellaneous Ethylcarbamate Aflatoxin Human.

Persistence of preclastogenic damage in hepatocytes of rats exposed to ethylnitrosourea, diethylnitrosamine, dimethylnitrosamine and methyl methanesulphonate. Correlation with DNA O-alkylation Participation of rat liver cytochrome P 2E1 in the activation of N -nitrosodimethylamine and N -nitrosodiethylainine to products genotoxic in an.

Molecular Dosimetry of O4-Ethyldeoxythymidine in Rats Continuously Exposed to Diethylnitrosamine Article (PDF Available) in Cancer Research 47(6) April with 22 Reads.

Pergamon Press pic Metabolism of diethylnitrosamine by microsomes of human respiratory nasal mucosa and liver (Received 12 October ; accepted 2 January ) Although the incidence of nasal tumors in the human population is low, certain individuals such as the workers in the leather or wood industry experience a higher risk of nasal cancer [1].

The formation and repair of carcinogen-DNA adducts in esophagus and liver of rats treated with a single i.p.

dose of methylbenzylnitrosamine (MBN), dimethylnitrosamine (DMN), diethylnitrosamine (DEN) or ethylnitrosourea (ENU) has been studied using peroxidase immunocytochemistry to visualize O 6-alkylguanine in DNA of individual MBN O 6. We examined the dose-dependency of gene expression changes for 51 genes in mouse liver treated with two N-nitroso genotoxic hepatocarcinogens, diethylnitrosamine (DEN) and ethylnitrosourea (ENU) by quantitative real-time PCR (qPCR).DEN (3, 9, 27 and 80 mg/kg bw) or ENU (6, 17, 50 and mg/kg bw) was injected intraperitoneally into groups of five male 9-week-old B6C3F 1 mice and the livers.

Tates, I. Neuteboon, A. Rotteveel, N. de Vogel, G. Menkveld and L. Den Engelse, Persistence of preclastogenic damage in hepatocytes of rat exposed to ethylnitrosourea, diethylnitrosamine, dimethylnitrosamine and methyl methanesulfonate-correlation with DNA O-alkylation, Carcinogenesis ().

PubMed CrossRef Google Scholar. Three doses of SJAMP ( mg/kg, 35 mg/kg, and 70 mg/kg administered 5 days/week via oral gavage) were given to rats with diethylnitrosamine (DEN)-induced HCC.

Synonym: Diethylnitrosamine CAS Number Linear Formula (C 2 H 5) 2 NNO. Molecular Weight Beilstein/REAXYS Number EC Number MDL number MFCD PubChem Substance ID NACRES NA. –Diethylnitrosamine –Dimethylbenz[a]anthracene –Dimethylnitrosamine –Ethylnitrosourea –3-Methylcholanthrene –N-Methylnitrosourea –Safrole –Urethane –Vinyl chloride •Chemicals with proposed non-mutagenic modes of action: –Amitrole –DDT –Dieldrin –Diphenylhydantoin –Ethylenethiourea –Polybrominated biphenyls Ethylnitrosourea (ENU) is a direct-acting alkylating agent (reviewed by Shibuya and Morimoto, ) that is well known to cause tumors in a variety of animal models including the Eker rat.8 days old rats were exposed to mg/kg b.

w. of either Methylnitrosourea (MNU) or Ethylnitrosourea (ENU). In the extraneural tissues mitotic inhibition lasts longer after MNU than after ENU. In the case of ENU, the number of mitotic cells rapidly increases once they reappear, whereas in the MNU-treated material reappearing mitotic figures are present in small numbers only at all intervals.